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This hypothesis is supported by the appearance of lesions of HFSR specifically in areas chronically exposed to friction and with preexisting hyperkeratosis.20 Recently, the existence of a genetic predisposition to develop sorafenib-induced HFSR has been described in patients with hepatocellular carcinoma.21 Dranitsaris et al.22 developed and validated a predictive model for the onset of HFSR in patients receiving treatment with sorafenib.23,24 The management of HFSR is summarized in Table 3

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It is crucial that clinicians conduct long-term follow-up and surveillance due to the potential risks for malignant transformation and local severe complications in some conditions

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This is strictly for the safety of the animal(s), and you will be notified by e-mail if this does occur

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Hvad viser forskningen: Koeth 2013 og senere observations-studier har koblet hjere TMAO med get risiko for hjertesygdom

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