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Description
Acyloxyalkyl esters are a general first prodrug for many new phosphonate containing compounds, since their first use to protect fosfomycin in 1969 (Figure 3) [7,16]
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So I arrive at a model where elongation happens in one compartment, and then the elongated fibrils must be trafficked inward to an acidic compartment where pH-dependent proteases fragment them, and then the fragmented fibrils must re-emerge to undergo elongation again
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McGuire, J
