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Gene therapy experiments in large animals will provide a better research perspective
The elevated PPP in cancer cells generates high NADPH levels to reduce ROS while simultaneously generating high levels of nucleotides for DNA synthesis and repair
Lukiw WJ, Bazan NG
Although many redox biosensors have been developed in recent years, only a few have been validated in model systems as suitable for studying disease-associated phenotypes 20,26,27,28
In vitro cytotoxicity studies confirm the absence of cellular toxicity at physiological and supraphysiological concentrations
