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Similar content being viewed by others Introduction Class B G protein-coupled receptors (GPCRs), whose endogenous ligands are peptide hormones, are key mediators of normal human physiology and serve as valuable drug targets for many diseases including diabetes, metabolic syndrome, osteoporosis, migraine, depression, and anxiety 1

The TRIUMPH program includes studies examining weight loss outcomes, cardiovascular endpoints, and comorbidity improvements like osteoarthritis pain relief

In the SURMOUNT-4 trial, withdrawing tirzepatide after initial weight loss led to weight regain, while continued treatment maintained and extended weight reduction

There are 64 million people globally living with heart failure, Novo Nordisk said in a statement about the trial results

The GLP-1R is widely expressed in multiple regions of the rodent and human brain, and activation of GLP-1R + neurons in the hypothalamus and brainstem reduces food intake and promotes weight loss