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Insulin resistance is primarily characterized by inhibition of hepatic glucose output and glucose uptake capacity, increased blood glucose levels and circulating free fatty acids

Research has already revealed a competitive relationship between acetylation and lactylation modifications at the H3K18 site, and inhibition of erasers has not yielded the anticipated restoration of lactylation levels [50]

1 Introduction Excessive alcohol consumption is a major global health concern, responsible for an estimated 4 -cell dysfunction and apoptosis through glucokinase nitration and its down-regulation

N Engl J Med 1988

Blood samples were collected over 24 h, however, baseline ascorbate values were not reported