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An optimal ratio comes into play when dealing with NAD+ and NADH

The primary cataplerotic reactions involve the enzymes glutamate dehydrogenase (GDH), aspartate transaminase (AST), and phosphoenolpyruvate carboxykinase (PEPCK)

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PDT-generated ROS damage tumor cell membranes and organelles, while the light-activated prodrugs achieve spatially controlled release of cytotoxic drugs inducing ICD locally at the tumor site

PMID: 41190713 Eur Cell Mater2025 Feb 20;49:55-70