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Cathartic therapy (not proven effective, but rational): Lactulose
doi: 10.3390/plants11162102 124 WangJ.LvP.YanD.ZhangZ.XuX.WangT.et al

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Thus, specific targeting of IGF-1R signaling post development may prove to be the best approach to achieve the benefits of low growth signals on healthspan and aging, without the potential unwanted side effects of combined adult-onset GH/IGF-1 deficiency
The Stanford-ADRC cohort is a longitudinal observational study of clinical dementia subjects and age-sex-matched nondemented subjects
