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however, an increasing number of studies over the past decade have indicate dthat the endoplasmic reticulum, as well as peroxisomes produce as much or even more ROS than the mitochondria (18,22)

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As COX17 serves as a primary copper donor in the IMS, 83 mutations in COX17 can reduce CCO activity and cause mitochondrial dysfunction and oxidative stress, 84 further supporting coppers significance in mitochondria

doi: 10.1073/pnas.2024358118 [DOI] [PMC free article] [PubMed] [Google Scholar] 252

Remember to consult with a healthcare professional before starting any new supplement regimen for personalized advice and recommendations