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The pro-inflammatory cytokines are excessively secreted from WAT in either genetic-based or diet-induced obese mice, which in turn interrupt insulin action in adipocytes, contributing to the onset and development of insulin resistance [60]

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At the same time, anti-obesity medications are typically prescribed as part of a comprehensive weight management plan

2013 Russell Ross memorial lecture in vascular biology: cellular and molecular mechanisms of diabetes mellitus-accelerated atherosclerosis Arterioscler Thromb Vasc Biol 34 4: 705-14

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