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Potentiation of ACh release through transcutaneous vagal neuromodulation is known to enhance gut motility, reduce inflammation by suppressing TNF- , and preserve epithelial tight junction integrity through the activation of enteric glial cells (243)

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Luteolin also exhibited potent regulatory effects on metabolic pathways, such as normalizing alterations in the arachidonic acid pathway, restoring the tricarboxylic acid (TCA) cycle, and eliminating metabolites implicated in pulmonary vascular remodeling [250]

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EV: Conceived the study, participated in its design and coordination and helped to draft the manuscript

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