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414 Very similar effects were caused by inhibiting glial glutamate transporters in the prefrontal cortex

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Skin inflammation and post-inflammatory hyperpigmentation Overproduction of ROS in melanocytes is also responsible for activation of signaling pathways such as NF-B, MAPK, and JAK/STAT, leading to increased expression of pro-inflammatory cytokines like IL-1, IL-6, and TNF-

Its called functional because the hormone-producing structures are still intact, but they arent working properly due to external or systemic influences

References 1 AbdulwahabD