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Caffeine is 95% metabolized by the hepatic cytochrome CYP1A2, which, additionally, is characterized by polymorphisms that affect the clearance rate of other compounds metabolized with this enzyme

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However, the clinical translation of such combination strategies still faces multiple challenges, including drug toxicity, cumulative side effects, dosage selection, and timing of administration

Watanabe, S

(33), who observed a significantly higher concentration of intracellular acetylcarnitine compared to carnitine in human erythrocytes, our results demonstrated that acetylcarnitine represented 0.1% in CON and 0.3% of all derivatives in CAR, compared to 6.2% and 22.9%, respectively, for carnitine