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The common problems are acute mountain sickness (AMS), insomnia, lack of appetite, tiredness, lethargy, upset stomach, disinclination to work, bone and muscle degradation, high-altitude pulmonary edema (HAPE), high-altitude cerebral edema (HACE), and all resulted in decrease in physical and mental performance in unacclimatized individuals [48]

Lastly, we hypothesized that SP might regulate numerous biological and pathological processes largely through its interaction with its specific receptor

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