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Armstrong EJ, Morrow DA, Sabatine MS

doi: 10.1038/nature07340

In this study however, the weight loss efficacy and tolerability profile of davalintide was not superior to pramlintide, and was inferior to the pramlintide/metreleptin combination, thus resulting in deciding to halt further development of davalintide

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The endogenous synthesis pathway involves two enzymes: arginine glycine acyltransferase (AGAT) and guanidinoacetic acid methyltransferase (GAMT) [33]