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This review discusses the development of novel antiobesity drugs based on current understanding of energy homeostasis Keywords: Obesity, Pharmacotherapy, Drug targets

[DOI] [PMC free article] [PubMed] [Google Scholar] 200.Weyer C, Tataranni PA, Snitker S, Danforth E, Jr, Ravussin E

In rodents and in humans genetic evidence demonstrates that the loss of SIM1 causes hyperphagic obesity in addition to causing resistance to the anorectic effects of melanocortins [68,69]

These include: Lifestyle interventions (dietary advice, physical activity programmes) Licensed pharmacotherapy such as orlistat, or GLP-1 receptor agonists including semaglutide 2.4 mg (Wegovy, NICE TA875) or tirzepatide (Zepbound) where clinically indicated and available Referral to tier 3 or tier 4 weight management services , including bariatric surgery assessment where appropriate Information on NHS weight management services and eligibility for licensed treatments is available via the NHS website and NICE guidance

Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet