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H.BastueL.MikutaviciusJ.SwiderskiP.ClemensK

Antibodies with a preferential role in ADCs must have the following characteristics: special targeting ability to deliver cytotoxic drugs to the tumor cells, high affinity binding to tumor cell-surface antigens and the ability to induce the cells endocytosis, low immunogenicity and the appropriate linkage sites which would not impact the affinity, endocytosis or efficacy of cytotoxic drugs [32]

Lactate-induced extracellular acidosis further contributes to immunosuppression by impairing tumor-infiltrating lymphocyte (TIL) function and promoting tumor invasiveness [210]

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Studies exploring the influence of curcumin on DNA methylation are summarized in Table 1