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Under pathological conditions such as calcium overload, higher ROS, ATP depletion, or ischemic injury, the mPTP can open transiently or persistently, leading to dissipation of the mitochondrial membrane potential, matrix swelling, and rupture of OMM [38,39,40,41]

doi:10.1038/s41598-025-97143-8 Dawson SL, Bowe SJ, Crowe TC

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