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GLP-1 Receptor Agonists and Glucagon/GIP/GLP-1 Receptor Dual or Triple AgonistsMechanism of Action and Emerging Therapeutic Landscape in #MASLD Bruno Ramos Molinas Post GLP-1 Receptor Agonists and Glucagon/GIP/GLP-1 Receptor Dual or Triple AgonistsMechanism of Action and Emerging Therapeutic Landscape in #MASLD

For instance, diabetes-induced chronic hyperglycemia, persistently-elevated free fatty acids and hyperinsulinemia all could lead to cardiac hypertrophy, intramyocardial inflammation, impaired mitochondrial function, and ultimately HF [4]

(9) Bone resorption is accomplished through the enzymatic activity of osteoclasts

The pathophysiology of this condition is incompletely understood but thought to be related to hypoperfusion of the optic nerve head leading to edema and infarction of optic nerve fibers (87, 88)