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consequently, MET or Hgf knockout embryos show markedly reduced liver size

Moreover, increased intracellular copper levels activate multiple signaling pathways, such as mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK/ERK) and B-rapidly accelerated fibrosarcoma (BRAF),which stimulate cell proliferation, promote angiogenesis via vascular endothelial growth factor (VEGF) activation (Pan et al., 2002), and enhance tumor invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) (Zhang et al., 2025)

However, there are no compelling prospective human data suggesting that either exogenous or endogenous hormones significantly influence tumor burden or growth rate across different sexes, or among individuals receiving hormone or anti-hormone therapies
