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Mechanical forces applied to connective tissues alter the gene expression pattern and activity of fibroblasts, as mechanical signals are converted into intracellular signalling events, a process called mechanotransduction

Cree-Green M, Cai N, Thurston JE, et al

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Furthermore, it is recognized that oxidative stress (linked to environmental and lifestyle factors) is primarily responsible for genetic and functional alterations in spermatozoa

[DOI] [PubMed] [Google Scholar] 36.Brown AJ, Sun L, Feramisco JD, Brown MS, Goldstein JL