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Possible role of the transglutaminases in the pathogenesis of Alzheimer's disease and other neurodegenerative diseases

261 In an uncontrolled trial in 47 subjects with fibromyalgia, 400 mg of oral SAMe twice daily plus 200 mg of intramuscularly injected SAMe once daily for six weeks decreased tenderness, increased general well-being, and improved scores measuring depression, anxiety, and mood