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Figure 1 2.1.4 Bile acids (BAs) as modulators in Alzheimer's brain-gut axis A potential therapeutic approach for AD consists of the BAs, which are produced in the liver (Grant and DeMorrow, 2020)
The dynamic instability within the Retromer accessory protein network is likely a feature in pathway progression and pathway fidelity that ensures directionality towards the successful biogenesis of a cargo-loaded transport carrier decorated with the appropriate RAB identity code, with post-translational modifications modifying and fine-tuning pathway progression by strengthening and weakening the avidity of Retromer network associations 123
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However, melatonin significantly counteracted these effects by reducing iNOS mRNA and protein levels, as well as NO production (Escames et al., 2003)
