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Historically the use of copper ionophores such as PBT2 have failed to produce efficacious results in clinical trials (Summers et al., 2022), but crucially they have been investigated without the addition of copper, probably due to the theory that it was primarily to disaggregate copper loaded plaques, in which case PBT2 would act as a chelator (Drew, 2017)
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Notably, both angiogenesis [50,51] and the NO-system [52,53,54,55,56,57] have been fundamental for healing since quite early in the cytoprotection concept
10, 26 Oct
