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In further support of this role of GDF11, a recent study identified a family with orofacial clefting and vertebral/rib hypersegmentation harboring a dominant-negative missense mutation in GDF11, in which an arginine is substituted for a glutamine at the furin protease cleavage site (R298Q) 51

Classe pharmaco-thrapeutique ANTIANMIQUE - VITAMINE B12 (B : Sang et organes hmatopotiques)
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