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doi:10.1159/000490284 Spiegel R, Kalla R, Mantokoudis G, et al
The function of T cells is closely related to the effect of immunotherapy, chemotherapy and other tumor treatments
Studies have used MT-II in direct comparison with MT-1 to characterise how cyclisation of the -MSH pharmacophore core changes receptor subtype selectivity , establishing that constraining the heptapeptide into a cyclic conformation shifts selectivity toward MC3R/MC4R relative to the linear tridecapeptide that preferentially activates MC1R
Patel, DP
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