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The accumulation of glutamate in the cytosol of astrocytes leads to the release of glutamate into the synaptic cleft

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The samples were centrifuged for 15 min at 4 C at 20.000 x g and 250 l were transferred into a new tube

doi: 10.1097/wco.0000000000000248 105

A select number of antidepressants and a wide range of anti-psychotic agents are glucuronidation ligands, but due to their delayed mechanism of action and pharmacokinetic properties the decrease of their plasma concentrations may not be immediately apparent and tends to present as a sudden and intense relapse of symptoms instead of a gradual regression to the behaviors and thought patterns exhibited by the patient prior to the initiation of their pharmacological treatment