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Radiologically, MMNSTs typically show T1 hyperintensity and T2 hypointensity on MRI due to intratumoral melanin ( For metastatic MMNST, ifosfamide plus doxorubicin is the most reported chemotherapy regimen, while fotemustine has shown partial remission in one case ( Anlotinibs efficacy in MPNSTs was recently suggested by Chen ( The prolonged disease control observed in this patient is likely attributable to the synergistic interplay among anlotinibs multifaceted antitumor mechanisms

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Some dust-like melanin granules may be present in a few tumor cells, and FontanaMasson staining may be required for their demonstration [43,45]

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The general organization of serotonin systems with a few serotonin-expressing neurons, multiple serotonin receptors, and widely distributed serotonin receptor-expressing neurons appears to be shared between mammals and C