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While the precise molecular pathways activated by neural PAR1 are yet under investigation, in the brain PAR1-activation has been shown to modulate synaptic transmission and plasticity through the enhancement of N-methyl-D-aspartate receptor (NMDAR) currents (Gingrich et al., 2007
Baskin DG, Schwartz MW, Seeley RJ, et al
This preparation permits intravital imaging of the unperturbed meninges and brain parenchyma
Strausak D, La Fontaine S, Hill J, Firth SD, Lockhart PJ, Mercer JF
Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation