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Description

DSIP A naturally occurring neuropeptide first isolated during slow-wave sleep, researched for sleep regulation, stress responses, pain perception, and potential applications in depression and substance withdrawal

View Article Neuro Endocrinology Letters (2001) "Peptides of pineal gland and consequences of their application in organism aging." View Article Advances in Gerontology (2014) "Peptide geroprotectors from the pituitary and pineal gland." Review of the mechanism of action

They consist of mitochondrial dysfunction affecting the cellular energy metabolism, calcium homeostasis in the heart affecting contractility of the myocardium, changes caused to the protein structure and function such as proteins in the extracellular matrix and contractile proteins, and post translational modifications that occur like O-GlcNAcylation and lysine - hydroxybutyrylation which are dysregulated in the diabetic heart (112)