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These observations suggest that besides modulating HSCs homeostasis, GPX4 may also have an important role in regulating monocyte and macrophage functions
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In contrast, our data suggest that xCT promotes L-cystine import and subsequent depletion of NADPH as L-cystine is reduced to L-cysteine, consistent with the model proposed by Goji et al
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Tamai I, Sai Y, Kobayashi H, Kamata M, Wakamiya T, Tsuji A