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The receptor type I of TGF-1, also known as activin receptor-like kinase 5 (ALK5), phosphorylates Smad2 and 3 with its serine-threonine kinase activity

Alternatively, PGC-1 may mediate the expression of motor proteins in spinal cord motoneurons and thus modulate movement disorders in an animal model of PD through the stimulation of the upstream promoter of the mitochondrial fusion-associated protein Mfn2 (Mou et al., 2021

Neuron 73 , 638652 (2012)

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