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Gupta, P

Incapsula incident ID: 569000120718876606-705180368151053106

This extraordinary potency arises from the combination of the D-phenylalanine substitution at position 7, which confers enzymatic resistance and enhanced receptor binding geometry, the Nle substitution at position 4 that prevents methionine oxidation, and the cyclic lactam constraint that pre-organizes the pharmacophore into the bioactive conformation

[DOI] [Google Scholar] 101.Ueno H., Yamakura S., Arastoo R.S., Oshima T., Kokubo K

Subjects/Methods Retrospective study of iris melanocytic tumours referred to tertiary referral centres in Auckland, NZ, over 20 years (1999-2018)