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Initially described in 1912, it became popular as a recreational drug in the 1970s and 1980s

The correlation between increased tirzepatide dosage and symptom exacerbation in the second case suggests a dose-dependent effect, potentially related to the drug's pharmacodynamics

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J Physiol Paris 93:505512 Sikiric P, Separovic J, Buljat G et al (2000) Gastric mucosal lesions induced by complete dopamine system failure in rats

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