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British journal of clinical pharmacology, 76(4), 516523

Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

SOCS proteins bind JAKs or their receptors and act by (i) abolishing the kinase ability of JAK, (ii) abolishing the ability of JAK to bind to the receptor, (iii) blocking STATs from being recruited to the receptor, and (iv) mediating the ubiquitination of JAKs and STATs for degradation (124)

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