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Goal: Support soft-tissue repair, recovery and angiogenesis TB-500 via actin-binding/cell migration and BPC-157 via preclinical tendon/gut/vascular healing

10.3390/molecules22010025 120 HowK

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By taking advantage of the potent catalytic activity of TYR that is mechanistically validated by ab initio molecular dynamics (AIMD) theoretical calculation and experimental catalysis performance, we develop a TYR-catalyzed in-situ formed proteolysis-targeting chimeras (PROTACs) to degrade intracellular TYR protein to decrease melanin synthesis for treating hyperpigmentation and a TYR-catalyzed in-situ activated prodrug strategy to overcome drug resistance for melanoma therapy