negative effects of glp 1 drugs liraglutide (GLP-1 receptor agonist) – Efficacy and Adverse GLP-1 medication side effects for
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119 and Jensterle et al
The study did, however, also highlighted several negative side effects, including constipation (118 occurrences), diarrhea (100 events), and abdominal pain (41 events per 1,000) (48)

doi:10.1111/dom.12926

In a seminal March 2021 New England Journal of Medicine study, adults receiving a weekly 2.4 mg injection of semaglutide for about 15 months lost 15% of their body weight35 pounds, on averagecompared to just 2.4% body weight loss in the placebo group

Moreover, functional MRI studies have demonstrated impaired connectivity within the default mode network in T2DM patients
