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Glutamate competitive and non-competitive ligands, binding to the same or to a different receptor site of the endogenous ligand, have been on development for at least three decades

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Gut microbial-related choline metabolite trimethylamine-N-Oxide is associated with progression of carotid artery atherosclerosis in HIV infection

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1996 (multicenter trial): A larger multicenter, randomized, double-blind, placebo-controlled study enrolled 431 patients with mild to moderate probable Alzheimer's disease, administering 3 g/day of ALCAR for 12 months