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doi: 10.1089/ars.2009.2940

When glutamine levels are low, pyruvate carboxylase, a regulatory enzyme of gluconeogenesis, can allow fibroblasts to use extracellular lactate to maintain TCA cycle anaplerosis, non-essential amino acid biosynthesis, and extracellular matrix collagen production in the tumor microenvironment [73]

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Despite decades of research, the molecular mechanisms behind axonal fusion are still elusive
However, two major limitations complicated the final evaluation and interpretation of this responsiveness
