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Compared to those with the CC and CT genotypes of MTHFR, those with the TT genotype had considerably higher blood tHcy concentrations ( p 0.001)

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Pb 2+ replace Ca 2+ in PKC activation and calmodulin (CaM) interactions, thereby disrupting downstream signaling cascades essential for mGluR function [19,88]

This results in sustained release, better tissue targeting, stronger mitochondrial protection, and improved redox balance.

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