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A 2025 human pilot study reported no adverse cardiac, hepatic, or renal effects at IV doses of 10-20mg

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doi: 10.1016/j.jneuroim.2008.09.005 [DOI] [PubMed] [Google Scholar] 45.Huang HY, Helzlsouer KJ, Appel LJ

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Staying hydrated throughout the day can help reduce your lower back pain by maintaining those discs full of liquid so they can cushion your spine through all the types of movements we put our bodies through and by preventing the muscles around your spine from an increase in lactic acid, which can cause inflammation, further pain, and compress the nerves surrounding your spine