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Furthermore, CYP3A1 emerges as one of the most significantly downregulated CYP450 isoforms under high-altitude exposure, suggesting gut microbiota as a key mediator of CYP3A1 modulationa plausible mechanism for hypoxia-driven microbial regulation of drug metabolism

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Binimetinib, Encorafenib, and Cetuximab Triplet Therapy for Patients With BRAF V600E-Mutant Metastatic Colorectal Cancer: Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study

Homology repair templates were amplified by PCR using primers that introduced a minimum of 35 base pairs of homology flanking the site of insertion at both ends