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Keywords : oxidative stress, endothelial dysfunction, GLP-1, autophagy, HDAC6 The prevalence of type 2 diabetes mellitus (T2DM) in China is 11.6% of the general adult population [1]

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In vitro stability assay with high glutathione concentration GLP-1MK-801 was dissolved in dimethyl sulfoxide at a concentration of 0.25 mM and diluted with a solution of 200 mM glutathione in PBS, pH 7, such that the final concentration of GLP-1MK-801 in the assay was 100 M

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While these therapeutic approaches have significantly improved outcomes among people with type 1 diabetes and CKD, this population remains at substantial elevated risk for adverse kidney and cardiovascular events, with limited improvements over the last few decades