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The single IGF-1 partial deficiency is responsible for mitochondrial dysfunction and is restored by IGF-1 replacement therapy

From cells to organs: the present and future of regenerative medicine

International Journal of Clinical and Experimental Medicine (2012) 5

The MR finding is stronger causal evidence than the LC3 observational findings in the previous section, because genetically predicted B12 cannot be influenced by disease or reverse causation

Treatment and prevention involve eating meat, fish, and dairy products or foods fortified with B12, like some breakfast cereals and breads
