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Higher doses (2000 mg/day) likely saturate hepatic OCTN2 transporters and elevate intracellular carnitine sufficiently to activate CPT1-mediated fatty acid oxidation

Minimal hepatic encephalopathy does not impair health-related quality of life in patients with cirrhosis: a prospective study

PMC 7507632

Moreover, IR in conjunction with activated immune-inflammatory, oxidative and nitrosative stress pathways may be implicated in neurotoxicity and depressive symptoms observed in LC [137]