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Description
For foot and ankle patients, weight reduction directly reduces mechanical load on the feet and joints, while the anti-inflammatory effects can improve outcomes in conditions such as plantar fasciitis, osteoarthritis, and peripheral neuropathy

Studies have documented analgesic effects comparable to moderate doses of conventional pain medications in animal models, with prolonged duration of action extending beyond the peptide's short plasma half-life suggesting central nervous system mechanisms of action

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Conversely, MMP-3 overexpression reduces collagen I levels in AD-MSCs (Rong et al., 2020), and its downregulation promotes NP-MSC chondrogenic differentiation (Zhang Q

Depression also prompts irregular eating behaviors and neglect of established management protocols, negatively influencing glycemic control [128]
