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The agency said the company failed to meet CGMP requirements, including implementing and adhering to its risk-based corrective and preventive action (CAPA) procedures

1 Serum markers of oxidative stress are elevated in patients with melasma, with a strong correlation observed between plasma glutathione peroxidase levels and severity of melasma.1, 3 In recent years, oral and topical antioxidants have shown to be effective in melasma treatment

Genetically engineered NF1-OPG models have been extremely useful to investigate the pathogenesis of NF1-OPG, which could somewhat be extended to general NF1-pLGGs

Identification of a variant antioxidant response element in the promoter of the human glutamate-cysteine ligase modifier subunit gene