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High oral doses are generally considered safe, though injectable B12 frequency should only be adjusted under medical supervision to ensure underlying causes of symptoms are properly investigated

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484 On the other hand, a similar study that analysed data from 2,841 acute heart attack patients found that, among 176 participants who received low-dose colchicine as part of treatment, the rate of all-cause mortality was 44% lower and the rate of cardiovascular disease-related mortality was 71% lower relative to those who did not receive colchicine during a median of 21.4 months of follow-up