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If supplementation is indeed required, it must be preceded by a careful consideration of the patients Se baseline status, gender, weight and so on ( 3.3 Dual role of Se deficiency in cretinism Cretinism often occurs in areas where endemic goiter is prevalent, with mucinous edema cretinism being the main manifestation of hypothyroidism without goiter

(107) demonstrated that even though prednisolone increased serum total and bioactive IGF-I, post-IGF-IR signaling was inhibited indicating that prednisolone-induced increases in serum IGF-I levels is not accompanied by increased IGF-I action

doi: 10.1016/j.ygeno.2021.01.022 70 ShuK.LiuX

doi: 10.1371/journal.pone.0155203

Before approving a new drug, the FDA typically requires companies to conduct a type of study called a randomized controlled trial, in which study participants are allocated by chance to groups that either receive the drug, or are administered a placebo