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Such drugs therefore need to be administered at more frequent dosing intervals

However, the generation of large amounts of lipid ROS during stroke disrupts this oxidative balance, resulting in both a large accumulation of lipid ROS and the development of peroxidation, which is the main feature of ferroptosis (42)

[DOI] [PMC free article] [PubMed] [Google Scholar] Li J, Qi J, Tang Y, Liu H, Zhou K, Dai Z, et al

PMID 33328986

This cerebellar phenotype results specifically from inappropriate stimulation of the TRa1 receptor isoform, since the additional deletion of TRa1 reversed the cerebellar phenotype