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and C.H.P.) independently extracted the following information: first author, year of publication, study design, study period, country, baseline characteristics of the study participants, dosage of target drugs, proportion of participants with ALT normalization, post-treatment serum AST and ALT levels, and other major findings of each study

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Western blot analysis of SEM and KOPN8 exposed to 500 nM of MEK inhibitor or vehicle control (DMSO) for 6, 24 and 48 hours